Why is a dextrose-containing IV solution given after TPN infusion?

• A. To prevent hypoglycemia
• B. To prevent hyperglycemia
• C. To prevent hyponatremia
• D. To prevent dehydration

Answer: (A)

When TPN stops, the body can swing into hypoglycemia because the continuous glucose supply ends while insulin levels from the prior high glucose load may still be high. Providing a dextrose-containing IV solution during the transition keeps glucose in the bloodstream as the body rights itself and switches back to endogenous glucose production or oral intake. This prevents the common and potentially dangerous drop in blood sugar that can occur after stopping TPN. It’s not about preventing high blood sugar, or about electrolyte or fluid balance directly, but about maintaining stable glucose levels during the transition. Monitor glucose closely during this period and adjust as needed.